类风湿因子(RF)是机体针对天然及变性、凝集IgFc部分产生的一组异常Ig的总称。1939年Waler在类风湿性关节炎(RA)患者血清中首先发现并命名,1948年Rose将其用于RA的临床诊断。现认识到RF与人类自身免疫现象和多种疾病密切相关,且在某些疾病中具有重要的病理意义。 Rheumatoid factor (RF) is a collective term for a group of abnormal Ig produced by the body against both native and denatured, aggregated IgFc moieties. In 1939, Waler was first discovered and named in the serum of patients with rheumatoid arthritis (RA). In 1948, Rose used it for the clinical diagnosis of RA. It is recognized that RF and human autoimmune phenomena and a variety of diseases are closely related, and in some diseases have important pathological significance.