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目的探讨中国汉族人群中载脂蛋白A5(APOA5)-1131T>C(rs662799)多态性与缺血性脑卒中的关系。方法选择1119例缺血性脑卒中患者和1027例健康居民作为对照,采用Taqman-MGB探针对载脂蛋白A5-1131T>C位点基因多态性进行检测,并通过文献检索,对符合标准的文献进行荟萃分析,全面探讨中国人群中载脂蛋白A5-1131T>C多态性与缺血性脑卒中的关系。结果研究表明载脂蛋白A5-1131T>C单核苷酸多态性不同等位基因频率和基因型在缺血性脑卒中组和正常对照组分布未见显著统计学差异。校正传统危险因素logistic回归分析显示在隐性模型下,APOA5-1131T>C与血栓性脑卒中相关(p=0.036),荟萃分析结果表明APOA5-1131C等位基因与中国汉族人群脑卒中发生的危险性无相关关系(OR=1.18,95%CI=0.90-1.54)。结论在中国人群中,APOA5-1131T>C多态性与缺血性脑卒中无相关性。
Objective To investigate the association between apolipoprotein A5 (APOA5) -1131T> C (rs662799) polymorphism and ischemic stroke in Chinese Han population. Methods A total of 1119 ischemic stroke patients and 1027 healthy residents were selected as controls. The gene polymorphisms of apolipoprotein A5-1131T> C locus were detected by Taqman-MGB probe. Meta-analysis of the literature, a comprehensive study of Chinese population apolipoprotein A5-1131T> C polymorphism and ischemic stroke. Results The study showed no significant difference in allele frequencies and genotypes of apolipoprotein A5-1131T> C SNP between ischemic stroke group and normal control group. Logistic regression analysis of traditional risk factors showed that APOA5-1131T> C was associated with thrombotic stroke (p = 0.036) in the recessive model. The meta-analysis indicated that the APOA5-1131C allele was associated with a risk of stroke in Chinese Han population No correlation (OR = 1.18, 95% CI = 0.90-1.54). Conclusion There is no correlation between APOA5-1131T> C polymorphism and ischemic stroke in Chinese population.