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本文考察了呋喃妥因肠溶微囊的体外溶出行为,用尿药法研究了其人体内的生物利用度并与市售肠溶片进行比较。体外溶出试验结果表明呋喃妥因肠溶微囊于人工胃液中药物释放降低,人工肠液中快速释放。肠溶微囊人体内生物利用度明显高于市售片。
In this paper, the in vitro dissolution behavior of nitrofurantoin enteric-coated microcapsules was investigated. The bioavailability of nitrofurantoin enteric-coated microcapsules was investigated by urinary drug method and compared with the commercially available enteric-coated tablets. In vitro dissolution test results showed that nitrofurantoin enteric-coated microcapsules in the artificial gastric juice in the drug release decreased rapidly in artificial intestinal fluid. Enteric microcapsules in vivo bioavailability was significantly higher than the commercially available tablets.