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目的 研究Cajal Retzius(CR)和非Cajal Retzius(NCR)神经元在新生儿大脑 13个皮质区的分布、相应密度和可能的亚型。方法 采用免疫组织化学方法检测新生儿大脑皮质神经元数目及分布。结果 (1)PV免疫反应阳性CR细胞见于所有的新皮质区 ,这些区域在第一层深部也发现PV ir水平纤维丛。 (2 )许多PV irCR细胞显示退行性变的明显标志。 (3)除大的CR细胞外 ,小的PV irNCR神经元也出现在新皮质区。它们包括不同的形态学种类 ,可以区分为几种亚型。结论 NCR细胞高密度地出现于第一感觉区 3、1、17和 4 1区。由于PV irNCR细胞密度在各区的差异 ,PV irCR与PV irNCR的比率在第一感觉区相对较低。目前对出生早期大鼠躯体感觉皮质的研究报道第一层存在复杂的相关的神经元间自发作用的时空模式。一个很大的可能性就是区域多样的神经元活性可能在不同脑区皮质环路中起主要作用。
Objective To investigate the distribution, corresponding densities and possible subtypes of Cajal Retzius (CR) and non-Cajal Retzius (NCR) neurons in 13 cortical regions of neonatal brain. Methods Immunohistochemistry was used to detect the number and distribution of neurons in neonatal cerebral cortex. Results (1) PV-immunoreactive CR cells were found in all neocortical areas, where PV ir horizontal fiber plexus was also found deep in the first layer. (2) Many PV irCR cells show signs of degeneration. (3) In addition to large CR cells, small PV irNCR neurons also appear in the neocortical area. They include different morphological species, which can be divided into several subtypes. Conclusion NCR cells appear in the first sensory zone 3, 1, 17 and 4 1 area with high density. Due to the difference in PV irNCR cell density in each zone, the ratio of PV irCR to PV irNCR is relatively low in the first sensory zone. Current studies of somatosensory cortex in early-born rats reported that there is a complex spatiotemporal pattern of spontaneous interaction between neurons in the first layer. A great possibility is that a diverse range of neuronal activities in the area may play a major role in different cortical circuits in the brain.