目的对2012-2014年郴州市手足口病流行特征进行分析,为预防和控制手足口病疫情提供科学依据。方法采用描述性流行病学对郴州市2012-2014年手足口病监测数据进行整理分析。结果 2012-2014年,郴州市共报告手足口病病例33 587例,年均报告发病率为241.89/10万,3年报告发病率差异有统计学意义(χ2=2 610.41,P<0.05)。报告重症病例579例,其中死亡16例,3年报告的病重率差异均有统计学意义(χ2=431.355,P<0.05);流行呈明显季节性,4-7月为发病高峰;3岁及以下儿童为主,每年占86%以上,男性多于女性;以散居儿童为主,每年占86.12%以上。2012年以HEV71感染为主(61.71%),2013年和2014年以其他HEV感染为主(81.36、48.57%);2012年重症病例以HEV71感染为主(75.08%),2013年以其他HEV感染为主(77.42%),2014年以HEV71和其他HEV感染为主。结论2012-2014年郴州市手足口病的报告发病率和病重率存在年度差异;每年的4-7月,3岁及以下的散居儿童是手足口病防控的重点;主要病原体在不同时间呈快速动态变化消长,重症病例的主要病原体不仅仅是HEV71。 Objective To analyze the epidemiological characteristics of HFMD in Chenzhou from 2012 to 2014 and provide a scientific basis for the prevention and control of HFMD. Methods Descriptive epidemiology was used to analyze the monitoring data of hand-foot-mouth disease in Chenzhou from 2012 to 2014. Results A total of 33 587 cases of hand-foot-mouth disease were reported in Chenzhou from 2012 to 2014, with an average annual incidence of 241.89 / lakh. The incidence of 3-year reported was statistically significant (χ2 = 2 610.41, P <0.05). 579 cases of severe cases were reported, of which 16 cases were dead. There was significant difference in the reported rates of severe diseases in 3 years (χ2 = 431.355, P <0.05); the epidemic was obviously seasonal and peaked in April-July; And below children, accounting for more than 86% each year, more men than women; mainly for scattered children, accounting for more than 86.12% each year. Infections were predominant in 2014 (61.71%) with other HEV infections in 2013 and 2014 (81.36, 48.57%). In 2012, HEV71 was predominant in severe cases (75.08%) and in 2013 with other HEV infections (77.42%). In 2014, HEV71 and other HEV infections were predominant. Conclusion There was an annual difference in the reported morbidity and severity of hand-foot-mouth disease in Chenzhou between 2012 and 2014. From April to July every year, scattered children aged 3 years and below were the focus of hand-foot-mouth disease prevention and control. Major pathogens were at different times The rapid dynamic change has shown that the major pathogens in severe cases are not only HEV71.