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目的:了解HPV L1壳蛋白联合HPV、Survivin检测在诊断宫颈癌前病变中的作用。方法:回顾性地对该医院妇科门诊2007年7月~2011年5月进行HPV L1壳蛋白联合HPV、Survivin检测的284例患者进行总结和分析。结果:HPV L1壳蛋白随着宫颈病变程度的加重呈现下降趋势,其在CINⅠ组和CINⅡ组中的阳性率显著高于对照组(P“,”Objective:To understand the role of joint detection of human papillomavirus(HPV) L1 capsid protein,HPV,and Survivin in diagnosis of cervical precancerous lesion.Methods:A total of 284 patients who received joint detection of HPV L1 capsid protein,HPV,and Survivin in gynecological outpatient department of the hospital from July 2007 to May 2011 were summarized and analyzed retrospectively.Results:The expression level of HPV L1 capsid protein showed a decreasing trend with aggravation of cervical lesions,the positive rates of HPV L1 capsid protein in cervical intraepithelial neoplasia(CIN) Ⅰ group and CIN Ⅱ group were statistically significantly higher than that in control group(P<0.05).The expression level of HPV showed an increasing trend with aggravation of cervical lesions,the positive rates of HPV in CIN Ⅰ group,CIN Ⅱ group,CIN Ⅲ group,and squamous cell carcinoma(SCC) group were statistically significantly higher than that in control group(P<0.05).The expression level of Survivin showed an increasing trend with aggravation of cervical lesions,the positive rates of Survivin in CIN Ⅲ group and SCC group were statistically significantly higher than that in control group(P<0.05).HPV L1 capsid protein expression was negatively correlated with HPV expression,while HPV expression was positively correlated with Survivin expression(P<0.05).Conclusion:Joint detection of HPV L1 capsid protein,HPV,and Survivin can be used as a biological marker to predict progress of cervical precancerous lesion.