创新霉素(Ⅰ)是一种具有独特结构类型的新抗生素,鉴于吡酮酸类抗菌药物分子中的苯环改换成毗啶环或嘧啶环之后其抗菌活性与药代动力学性质有较大改善,据此制备了以嘧啶环代替去氢创新霉素分子中苯环部份的化合物(Ⅱa),定名为去氢创新霉素 The novel antibiotic (Ⅰ) is a novel antibiotic with a unique structure type. In view of the fact that the antibacterial activity and the pharmacokinetic property of the pyridoxan antibacterial drug molecule after its conversion to a pyridine ring or a pyrimidine ring Greatly improved, thus prepared a pyrimidine ring instead of dehydro-modified neomycin molecule benzene ring part of the compound (IIa), named dehydro-Neomycin