在临床研究和高血压治疗中,钙拮抗剂已得到了更多的注意。在高血压病人中,钙拮抗剂具更强大的扩血管活性,因而促进了对它的研究。细胞内钙离子浓度对于增加血管平滑肌细胞张力是一决定因素。就调节平滑肌张力的所有神经激素和离子影响而言,游离钙为一焦点。尽管关于血管平滑肌细胞中膜受体和离子泵是如何影响慢通道钙流入的确切机理尚不完全清楚,但在原发性高血压的鼠及病人脂肪组织中观察到细胞内钙离子浓度增加。最近Erne等使用细胞内埋藏萤 Calcium antagonists have gained more attention in clinical research and in the treatment of hypertension. Calcium antagonists have a more potent vasoconstrictor effect in hypertensive patients, thus facilitating their investigation. Intracellular calcium concentration is a determinant of increased vascular smooth muscle cell tension. Free calcium is the focal point of all neurohormones and ions that regulate smooth muscle tone. Although the exact mechanism of how membrane receptors and ion pumps in vascular smooth muscle cells affect slow-pathway calcium influx is not fully understood, an increase in intracellular calcium concentration is observed in primary hypertensive mice and in adipose tissue of patients. Recently, Erne and other cells using the buried firefly