1993年以来,我们对258例早孕者采用口服米非司酮(Ru486)和前列腺素中止早孕,收到了良好效果。现报告并分析如下。 资料与方法:本组孕妇258例,年龄≤35岁,停经≤49天,B超检查或尿HCG测定确诊为早孕,均未放置宫内节育器,无子宫畸形及其他疾病史;用药前3个月未使用甾体类及肾上腺皮质激素类药物,无用药禁忌症。 用药方法:空腹或进食2小时后口服Ru486,每次25mg,每日服3次,连服2天;首次服药48小时后顿服米索前列醇0.6mg。服药后注意休息,严密观察阴道流血量,一旦有绒毛球排出,即携带来院确认。服药后6～8小时未见绒毛球排出或已排出者,均即刻肌注催产素10～20U促宫缩,并口服益母草冲剂3～5天协助排出胚囊或蜕膜,以减少阴道出血量。胚囊排出后阴道流血较多、长于8～14天或仍无胚囊排出者,应及时行B超检查。对不全流 Since 1993, 258 cases of early pregnancy by oral administration of mifepristone (Ru486) and prostaglandin termination of early pregnancy, received good results. Now report and analyze as follows. Materials and Methods: The group of 258 pregnant women, aged ≤ 35 years, menopause ≤ 49 days, B-ultrasound or urinary HCG determination of early pregnancy, no intrauterine device, no history of uterine malformations and other diseases; medication before 3 Month did not use steroids and adrenal hormones drugs, no drug contraindications. Medication: fasting or eating Ru486 2 hours after oral administration, each time 25mg, 3 times a day, and even served two days; 48 hours after the first dose of misoprostol 0.6mg. After taking medicine to rest, close observation of vaginal bleeding, once the villus discharge, that is, carry to the hospital to confirm. 6 to 8 hours after taking the drug did not see the villus discharge or have been discharged, are immediate intramuscular oxytocin 10 ~ 20U to promote contractions and oral motherwort granules 3 to 5 days to help discharge embryo sac or decidua to reduce vaginal bleeding . Vaginal discharge after blastocyst more, longer than 8 to 14 days or no blastocyst discharge should be promptly performed B-ultrasound. On the incomplete flow