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目的观察盐酸帕罗西汀治疗帕金森病患者抑郁症状的临床效果。方法选取我院2013年10—2014年10月收治的60例帕金森病抑郁症状患者为研究对象,随机分为对照组和观察组各30例。对照组患者给予帕金森病常规治疗,观察组患者则在对照组治疗的基础上使用盐酸帕罗西汀进行治疗。在治疗前后均采用汉密尔顿抑郁量表(HAMD)以及Webster评分评估两组患者的帕金森病神经症状,并观察其临床疗效。结果对照组与观察组治疗抑郁症状的总有效率分别为60.00%、90.00%,观察组的总有效率明显高于对照组,差异有统计学意义(P<0.05);对照组与观察组患者神经症状治疗的总有效率分别为63.33%、86.67%,观察组患者的总有效率显著高于对照组,差异有统计学意义(P<0.05)。结论盐酸帕罗西汀治疗帕金森病抑郁症状患者能提高治疗的有效率,并使得患者的帕金森病神经症状得到了有效改善,且用药安全、简单,值得在临床上广泛推广应用。
Objective To observe the clinical effect of paroxetine hydrochloride on depressive symptoms in patients with Parkinson’s disease. Methods Sixty patients with depressive symptoms of Parkinson’s disease admitted in our hospital from October 2013 to October 2014 were selected as study subjects and randomly divided into control group and observation group of 30 cases. Patients in the control group were given routine treatment of Parkinson’s disease, and patients in the observation group were treated with paroxetine hydrochloride on the basis of the control group. Before and after treatment, the Hamilton Depression Rating Scale (HAMD) and Webster score were used to evaluate the neurological symptoms of Parkinson’s disease in both groups, and the clinical efficacy was observed. Results The total effective rate of the treatment of depressive symptoms in the control group and the observation group was 60.00% and 90.00%, respectively. The total effective rate in the observation group was significantly higher than that in the control group (P <0.05). The control group and the observation group The total effective rate of neurological symptoms were 63.33% and 86.67%, respectively. The total effective rate in the observation group was significantly higher than that in the control group (P <0.05). Conclusion Paroxetine hydrochloride can effectively improve the treatment of depressive symptoms in patients with Parkinson’s disease and make the patients with neurological symptoms of Parkinson’s disease effectively improved. The medication is safe and simple, which is worthy of wide application in clinic.