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T细胞如何识别外来抗原,是免疫学的中心问题之一.主要组织相容性复合物(MHC)的限制作用和T细胞受体(TCR)的发现,以及TCR分子立体结构的阐明,终于确定了TCR-MHC-肽复合物在抗原识别及细胞免疫中的核心地位.由数以百万计的各种TCR分子组成的TCR库,赋于免疫系统识别外来抗原的巨大潜力.对TCR多样性及其和MHC-肽复合物相互作用的了解,不仅加深对细胞免疫反应机制的认识,并对探讨某些疾病的病因和发病机理提供了新的途径.
How T cells recognize foreign antigens is one of the central issues in immunology.The restriction of the major histocompatibility complex (MHC), the discovery of T cell receptor (TCR), and the elucidation of the stereostructure of TCR molecules were finally confirmed The TCR-MHC-peptide complex plays a central role in antigen recognition and cellular immunity. The TCR library, made up of millions of TCR molecules, gives the immune system great potential to recognize foreign antigens. The TCR diversity And their understanding of the interaction with the MHC-peptide complex not only deepen the understanding of the cellular immune response mechanism, but also provide a new way to explore the etiology and pathogenesis of certain diseases.