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胃癌是人类最常见的恶性肿瘤之一,位居消化道肿瘤之首。多年来,胃癌的发生发展及其侵袭转移一直是众多学者研究的热点。肝素酶(Hpa)是一类βD糖苷内切酶(endoβDglucuronidase),它既可存在于正常组织,也表达于多种恶性肿瘤细胞表面,以水解的方式降解组织屏障中的糖蛋白成分硫酸乙酰肝素糖蛋白(HSPGs),释放HSPGs结合的生物活性分子,促进细胞的侵袭和转移,诱导肿瘤血管生成,降低肿瘤患者的生存率。此文就Hpa与胃癌侵袭转移的关系作一综述。
Gastric cancer is one of the most common human malignant tumors, ranking the first of gastrointestinal tumors. Over the years, the occurrence and development of gastric cancer and its invasion and metastasis have been the hot spots of many scholars. Heparanase (Hpa) is a type of endoglucanase endoderm (endoβDlucuronidase), it can exist in normal tissues, but also expressed in a variety of malignant tumor cell surface, in a hydrolytic manner to degrade the glycoprotein component of the tissue barrier of acetyl sulfate Heparin glycoproteins (HSPGs) release bioactive molecules that HSPGs bind, promote cell invasion and metastasis, induce tumor angiogenesis, and reduce the survival rate of tumor patients. This article reviewed the relationship between Hpa and invasion and metastasis of gastric cancer.