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上皮-间质转化是一种正常的细胞生理发育过程,主要表现为上皮细胞通过特定程序转化为具有间质表型的细胞,上皮-间质转化在炎症反应、细胞发育、癌症侵袭转移等过程中发挥重要作用而且与前列腺癌干细胞有一定的相互联系。最新研究表明,前列腺癌的发生发展转移中出现了上皮-间质转化的转变过程,本文着重回顾了最新的相关文献,就上皮-间质转化在前列腺癌疾病进展过程中具体的作用及其机制进行综述。
Epithelial-mesenchymal transition is a normal process of cell physiological development, mainly manifested as epithelial cells transformed into cells with mesenchymal phenotype by a specific program. Epithelial-mesenchymal transition is involved in inflammatory reaction, cell development, cancer invasion and metastasis In play an important role and with prostate cancer stem cells have a certain relationship. Recent studies show that there is a transitional process of epithelial-mesenchymal transition in the development and progression of prostate cancer. In this review, we review the most recent literature on the role and mechanism of epithelial-mesenchymal transition in the progression of prostate cancer For review.