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目的:观察中药联合时辰化疗对治疗中晚期大肠癌的临床疗效和不良反应。方法:将90例中晚期大肠癌患者分成3组各30例,A组采用FOLFOX6常规化疗,B组采用择时辰FOLFOX6化疗,C组采用四君子汤加味联合时辰FOLFOX6化疗。14d为1个周期,2个周期评定3组的近期疗效和不良反应。结论:总有效率A组为33.3%,B组为53.3%,C组为60.0%,B组、C组与A组比较,差异有统计学意义(P<0.05),B组与C组比较,差异无统计学意义(P>0.05)。不良反应发生率C组明显低于A组和B组,两两比较,差异均有统计学意义(P<0.05)。结论:中药联合时辰化疗治疗中晚期大肠癌有效率高,不良反应小。
Objective: To observe the clinical efficacy and adverse reactions of traditional Chinese medicine combined with chemotherapy on the treatment of advanced colorectal cancer. Methods: 90 patients with advanced colorectal cancer were divided into 3 groups of 30 cases. Group A received FOLFOX6 routine chemotherapy. Group B received selective FOLFOX6 chemotherapy. Group C received Sijunzi Decoction combined with FOLFOX6 chemotherapy. 14d for a cycle, two cycles assessment of the 3 groups of short-term efficacy and adverse reactions. Conclusion: The total effective rate in group A is 33.3%, in group B is 53.3% and in group C is 60.0%. There is significant difference between group B and group C and group A (P <0.05) , The difference was not statistically significant (P> 0.05). The incidence of adverse reactions in group C was significantly lower than that in group A and group B, and the difference was statistically significant (P <0.05). Conclusion: Chinese medicine combined with chemotherapy for advanced colorectal cancer with high efficiency, small adverse reactions.