论文部分内容阅读
目的 探讨爆震后豚鼠耳蜗残存螺旋神经节细胞分布特点及超微结构改变。方法 复制爆震致聋豚鼠模型．取耳蜗做病理检查，观察耳蜗残存螺旋神经节细胞分布特点及其超微结构变化。结果 爆震组２１ｄ的耳蜗螺旋神经节细胞在耳蜗中轴切片的二下部位为（２７．０±６．９）个；而正常对照组耳蜗中轴切片的二下部位为（５１．０±４．７）个，两组间统计学差异有显著意义。豚鼠螺旋神经节细胞透射电镜观察爆震组震后 ３ ｄ出现明显线粒体肿胀，线粒体峙断裂；２１ｄ后线粒体数量明显减少，且有畸形。而同期的正常对照组未发生上述现象。结论 爆震后耳蜗螺旋神经节细胞数量减少，残留神经细胞线粒体超微结构有明显病变。
Objective To investigate the distribution and ultrastructural changes of residual spiral ganglion cells in guinea pig cochlea after detonation. Methods Duplicate detonation induced guinea pig model. The cochlea were taken for pathological examination to observe the distribution and ultrastructural changes of residual spiral ganglion cells in the cochlea. Results The cochlear spiral ganglion cells in the knock group 21d had (27.0 ± 6.9) inferior segments in the central axis of the cochlea, while those in the control group had (51.0 ± 4.7), the statistical difference between the two groups was significant. Transmission electron microscope observation of guinea pig spiral ganglion cells showed obvious mitochondrial swelling and mitochondrial rupture at 3 days after detonation. After 21 days, the number of mitochondria decreased obviously and deformity was observed. The same period of the normal control group did not happen the above phenomenon. Conclusion The number of spiral ganglion cells in dendritic cells decreases after detonation, and the ultrastructural changes of mitochondria in residual neurons have obvious changes.