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目的研究探讨不同剂量米非司酮用于紧急避孕的结果,总结其临床用药经验及临床意义。方法选取我院2009年8月至2011年8月避孕失败或者无保护下性交后120h内就诊的妇女84例,均给予米非司酮进行紧急避孕处理,按照使用剂量分为四组,各21例,A组(单次给药10mg)、B组(单次给药25mg)、C组(单次给药75mg)、D组(单次给药150mg),观察比较四组的避孕成功率,药物副反应发生率及阴道点滴出血率、月经延迟发生率。结果在避孕成功率方面,以D组最高,与A组比较有明显差异(X2=9.62,P<0.01),具有统计学意义;在药物副反应(恶心、呕吐、下腹痛、头晕、乳房胀痛等轻微症状,均无需特殊处理,能自行缓解)发生率方面,以D组最高,其次为C组,皆明显高于A、B组,差异显著(X2=116.40,101.96,11.83,6.07,P<0.05),具有统计学意义。结论不同剂量米非司酮用于紧急避孕皆有良好的效果,但临床认为使用小剂量(单次给药10mg、15mg)米非司酮进行紧急避孕能够明显减少药物的副反应,且效果也肯定,属于较为理想的用药方案,但不同剂量的米非司酮对于月经改变的研究仍缺少有力依据,仍待进一步考究。
Objective To study the effects of different doses of mifepristone on emergency contraception and to summarize its clinical experience and clinical significance. Methods Eighty-four women who received treatment within 120 hours after sexual intercourse were admitted to our hospital from August 2009 to August 2011 were enrolled in this study. All patients were given mifepristone for emergency contraception. The patients were divided into four groups In group A (single administration of 10 mg), group B (single administration of 25 mg), group C (single administration of 75 mg) and group D (single administration of 150 mg), the contraceptive success rates , The incidence of side effects of drugs and vaginal drip rate, the incidence of delayed menstruation. Results The success rate of contraception was the highest in group D, which was significantly different from that of group A (X2 = 9.62, P <0.01), and was statistically significant. The side effects of drugs (nausea, vomiting, abdominal pain, dizziness, Pain and other mild symptoms, no special treatment, to ease their own), the highest in the D group, followed by the C group were significantly higher than the A, B group, the difference was significant (X2 = 116.40,101.96,11.83,6.07, P <0.05), with statistical significance. Conclusion Different dosage of mifepristone has good effect in emergency contraception. However, it is clinically considered that the emergency contraception with low dose (single administration of 10 mg, 15 mg) of mifepristone can significantly reduce side effects of drugs and the effect is also Certainly, is a more ideal drug regimen, but different doses of mifepristone on the study of menstrual changes is still a lack of strong basis, still need further study.