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本文总结了使用环孢素(CyA)行抗排异治疗的366例肾移植病人出现肝功能异常的临床资料。其肝毒性的发生率为25.68％(94/366);死亡13例;肝毒性的发生时间为7～84d,持续时间5～96d。结果表明:HBsAg阳性,原有肝功能异常及老年病人不适宜使用CyA。
This article summarizes the use of cyclosporine (CyA) anti-rejection treatment of 366 cases of kidney transplant patients with liver dysfunction clinical data. The incidence of hepatotoxicity was 25.68% (94/366). Thirteen died. The onset of hepatotoxicity was 7-84 days and the duration was 5-96 days. The results show that: HBsAg-positive, the original liver dysfunction and elderly patients are not suitable for the use of CyA.