目的:了解育龄妇女使用Norplant后阴道异常出血的可接受性和对维生素E(VitE)、低剂量阿斯匹林单独/合并治疗效果的调查。方法:采用前瞻性、随机、双盲的研究方法,对受试者按WHO/HRP提供的随机分配表,将对象分配到阿司匹林、VitE、VitE+阿司匹林、安慰剂4组。结果:各组受试者选择皮下埋植避孕的理由无差异。长期阴道出血对宗教信仰、探亲访友、家务及衣着无影响.17.7%对象感到疲劳,25.4%对象阴道出血期间感腰痛,因长期阴道出血,大多数丈夫及妻子均认为阴道出血时应避免性生活。大多受试者认为治疗有效。各治疗组组间及与安慰剂组治疗效果比较无显著性差异。治疗前、后血红蛋白比较无显著性差异。结论:Norplant皮下埋植剂引起妇女长期阴道出血,对其日常生活、工作未引起明显影响,但对性生活有一定影响.vitE、阿斯匹林治疗未显示明显的疗效。 OBJECTIVE: To investigate the acceptability of vaginal abnormal bleeding in women of reproductive age after Norplant and the effects of vitamin E and low-dose aspirin alone or in combination. METHODS: A prospective, randomized, double-blind study was conducted in which subjects were assigned to aspirin, VitE, VitE + aspirin, and placebo in a randomized allocation table based on WHO / HRP. RESULTS: There was no difference in the reasons for subcutaneous implantation of contraception in each group of subjects. Long-term vaginal bleeding had no effect on religious beliefs, visiting relatives and friends, housework and clothing, while 17.7% of the subjects felt tired and 25.4% of the subjects felt vaginal bleeding during the period. Due to long-term vaginal bleeding, most husbands and wives considered that vaginal bleeding should be avoided life. Most subjects considered the treatment effective. There was no significant difference between the treatment groups and the placebo group. There was no significant difference in hemoglobin before and after treatment. Conclusion: Norplant subcutaneous implants cause long-term vaginal bleeding in women, but have no obvious effect on their daily life and work, but have some influence on their sexual life. VitE and aspirin have no obvious curative effect.