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本文对120例粪检(粪便虫卵孵化法)阳性的血吸虫病人于治疗前和经吡喹酮治疗后1、3、6、12月进行粪检和以酶标记免疫吸附试验(ELISA)测定病人血清抗体,确定后一种方法作判定药物治疗效果的价值。结果表明,120例病人在治疗后多次粪检均为阴性,而ELISA随时间的推移其阳性率,平均光吸收值与其几何平均倒数滴度(GMRT)均逐渐下降。治疗半年至一年后,50％至70％的病人的ELISA转为阴性,平均光吸收值降为原1/3～1/4,GMRT从478.4降为158.8～100.0。作者认为,ELISA对评价药物的治疗效果有一定的参考价值。这一方法敏感,光吸收值下降快,似乎较最常用的环卵反应具有更多的优点。
In this paper, 120 cases of schistosomiasis (stool egg hatching method) -positive schistosomiasis patients before treatment and after praziquantel treatment of 1,3,6,12,12 months for fecal examination and enzyme-linked immunosorbent assay (ELISA) determination of patients Serum antibodies, to determine the value of a method for determining the effect of drug treatment. The results showed that 120 patients were negative for many stool tests after treatment, while the positive rate, mean optical absorbance and geometric mean reciprocal titer (GMRT) of ELISA decreased gradually with the passage of time. After half a year to one year of treatment, ELISA turned negative in 50% to 70% of patients. The average light absorbance was reduced to 1/3 ~ 1/4 and GMRT decreased from 478.4 to 158.8 ~ 100.0. The authors believe that, ELISA evaluation of the therapeutic effect of the drug has a certain reference value. Sensitive to this method, the light absorption decreases rapidly and seems to have more advantages than the most commonly used ring-and-egg reaction.