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乙型肝炎发病机制主要包括细胞毒性T淋巴细胞(CTL)介导的肝细胞损伤坏死和肝细胞凋亡。CD4阳性Th1细胞也可引起肝细胞凋亡。细胞间粘附分子-1(ICAM-1)系免疫球蛋白超家族成员,与其配体淋巴细胞功能相关抗原-1(LFA1)参与介导淋巴细胞与靶细胞及淋巴细胞间的粘附。国内外研究表明,ICAM-1在病毒性肝炎、内毒素血症所致肝损坏死、缺血后再灌流所致肝损伤、自身免疫性肝损伤及酒精性肝损伤中起重要作用。人白细胞抗原(HLA)Ⅱ类分子在乙
The pathogenesis of hepatitis B mainly includes cytotoxic T lymphocyte (CTL) -mediated hepatocyte injury and necrosis and hepatocyte apoptosis. CD4-positive Th1 cells can also cause hepatocyte apoptosis. Intercellular adhesion molecule-1 (ICAM-1), a member of the immunoglobulin superfamily, is involved in the mediation of lymphocyte adhesion to target cells and lymphocytes with its ligand, LFA1. Domestic and foreign studies have shown that ICAM-1 plays an important role in viral hepatitis, hepatic necrosis caused by endotoxemia, liver injury caused by reperfusion after ischemia, autoimmune liver injury and alcoholic liver injury. Human leukocyte antigen (HLA) class II molecules in B