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已经证实,烷化剂治疗卵巢癌有增加急性白血病的危险,既往的研究虽已确认多种化疗药物与白血病有关,但允许这种危险性的确认,其材料尚不够大。本文采用病例对照设计,由包括加拿大、丹麦、芬兰、挪威、德国、英国、南斯拉夫在内的11个癌症登记处和2个肿瘤医院有关人员组成的国际性癌症协作组对1960年1月以来诊断为卵巢癌后发生白血病的病例进行研究,以确定化疗、放疗及其他因素对白血病发生可能的病因学作用。研究期间,99113例卵巢癌患者治疗后共发现144例白血病。每个白血病病例以3个相匹
It has been confirmed that alkylating agents have an increased risk of acute leukemia in the treatment of ovarian cancer. Although previous studies have confirmed that a variety of chemotherapeutic drugs are related to leukemia, the confirmation of this risk is permitted and the material is not large enough. This article uses a case-control design and the international cancer cooperation group consisting of 11 cancer registries, including Canada, Denmark, Finland, Norway, Germany, the United Kingdom, and Yugoslavia, and two tumor hospital personnel diagnosed since January 1960 A case of leukemia after ovarian cancer was studied to determine the possible etiological effects of chemotherapy, radiotherapy, and other factors on leukemia. During the study period, a total of 144 cases of leukemia were found after the treatment of 99113 ovarian cancer patients. Each leukemia case has 3 phases