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目的探讨肿瘤合并HIV病毒感染患者的感染途径和细胞免疫功能变化。方法以肿瘤合并HIV病毒感染患者为实验组,单一肿瘤疾病患者为对照组,每组104例,应用流式细胞仪检测外周血NK细胞和T细胞亚群水平,包括CD3+、CD4+、CD8+细胞百分比及CD4+/CD8+比值等。分析肿瘤患者HIV感染的途径分布及构成比。结果实验组外周血NK和CD4+细胞数量百分率及CD4+/CD8+比值偏低,CD8+数量百分率升高,差异有统计学意义(P<0.05),2组CD3+细胞数量百分率变化不明显,差异无统计学意义(P>0.05)。肿瘤患者感染途径主要是临床输血和有偿供血,分别占41.35%和18.27%。结论通过肿瘤合并HIV病毒感染患者感染途径和免疫功能变化的分析,对了解患者的免疫状态、易染途径、疾病的诊断、治疗和预后均有积极的意义。
Objective To investigate the pathways of infection and cellular immunity in patients with tumor complicated with HIV infection. Methods Tumor patients with HIV infection were selected as experimental group and single tumor patients as control group, with 104 patients in each group. The levels of peripheral NK cells and T lymphocyte subsets including CD3 +, CD4 + and CD8 + cells were determined by flow cytometry And CD4 + / CD8 + ratio and so on. Analysis of tumor patients with HIV infection pathway distribution and composition ratio. Results The percentage of NK and CD4 + cells and the ratio of CD4 + / CD8 + in peripheral blood were lower and the percentage of CD8 + increased in experimental group (P <0.05). There was no significant difference in the percentage of CD3 + cells between two groups Significance (P> 0.05). Tumor patients were mainly infected with clinical blood transfusion and paid blood, accounting for 41.35% and 18.27%. Conclusion The analysis of the infection pathways and the changes of immune function in patients with HIV-infected neoplasms is of positive significance in understanding the immune status, easy pathways of infection, diagnosis, treatment and prognosis of the patients.