目的观察新型鼻塞持续气道正压通气(N-CPAP)结合肺表面活性物质(PS)治疗新生儿呼吸窘迫综合征(NRDS)的疗效。方法应用N-CPAP结合PS治疗NRDS患儿70例,所有患儿均作气管插管,气管内注入PS,拔除气管插管后给予N-CPAP。结果治疗10d后,70例患儿中,治愈65例(92.9%),吸入氧浓度(FiO2)、氧分压(PaO2)、二氧化碳分压(PaCO2)得以明显改善;放弃治疗5例。结论 N-CPAP结合PS治疗NRDS效果好,可提高患儿的生存质量。 Objective To observe the effect of nasal continuous positive airway pressure (N-CPAP) combined with pulmonary surfactant (PS) on neonatal respiratory distress syndrome (NRDS). Methods 70 children with NRDS were treated with N-CPAP combined with PS. All children were treated with endotracheal intubation, PS with endotracheal intubation, and N-CPAP with endotracheal intubation. Results After 70 days of treatment, 65 cases (92.9%) were cured and the FiO2, PaO2 and PaCO2 were significantly improved in 70 cases. 5 cases were abandoned. Conclusion N-CPAP combined with PS treatment of NRDS good effect, can improve the quality of life in children.