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目的针对患有萎缩性阴道炎的患者展开临床治疗对比研究,旨在完善临床用药方法,提升药物治疗有效性。方法调查我市妇幼保健院2011年10月-2013年10月这两年时间内收治的萎缩性阴道炎患者共90例。通过回顾性研究这些患者临床资料,了解在使用甲硝唑基础上另采用雌激素治疗的优化效果。将这90例患者随机分为对照组及观察组。对照组患者采用单纯甲硝唑用药方法,观察组在此基础上另加雌激素治疗。对比两组患者治疗效果以及阴道恢复情况。结果观察组患者治疗效果明显优于对照组患者(P<0.05),两组患者在子宫内膜厚度以及表层细胞恢复方面均较治疗前有所优化,但观察组患者优化效果更为明显,且表层细胞数量增加幅度明显多于对照组。结论在甲硝唑药物基础上另加雌激素能够有效改善患者子宫环境,将子宫中真菌等造成萎缩性阴道炎的物质杀灭,促使子宫表层细胞数量增多,从而达到治疗效果。因此这一用药方式适合在临床上推广使用。
Aim To compare the clinical treatment of patients with atrophic vaginitis, aiming to improve the clinical medication and improve the effectiveness of drug treatment. Methods A total of 90 patients with atrophic vaginitis were admitted to our MCH from October 2011 to October 2013 in the past two years. By retrospectively studying the clinical data of these patients, we learned about the optimal effect of estrogen therapy based on metronidazole. The 90 patients were randomly divided into control group and observation group. Patients in the control group were treated with metronidazole alone, and the observation group was additionally treated with estrogen. Comparison of two groups of patients treatment and vaginal recovery. Results The therapeutic effect of the observation group was significantly better than that of the control group (P <0.05). The two groups of patients were better than the pre-treatment in the thickness of the endometrium and the recovery of the superficial cells. However, the optimization effect was more obvious in the observation group The number of surface cells increased significantly more than the control group. Conclusion The addition of estrogen on the basis of metronidazole can effectively improve the uterine environment in patients with uterine fungi and other substances that cause atrophic vaginitis to kill, prompting an increase in the number of uterine surface cells, so as to achieve the therapeutic effect. Therefore, this medication is suitable for clinical use.