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目的考察乌司他丁(ulinastatin,UTI)在早期烧伤患者中的应用价值。方法选取2013-11-2015-06我院住院的130例烧伤患者作为研究对象,并随机分为UTI组(n=65)和对照组(n=65)。给予对照组患者常规急救治疗,在对照组基础上给予实验组UTI治疗。比较两组患者相同时间血清内肿瘤细胞坏死因子-α(TNF-α)及白介素-8(IL-8)水平,尿素氮、血肌酐、总胆红素、丙氨酸转氨酶的水平,全身性炎症反应综合征(systemic inflammatory response syndrome,SIRS)及器官功能障碍综合征(multiple organ dysfunction syndrome,MODS)的发生率。结果相同的治疗时间后,UTI组患者TNF-α及IL-8水平,尿素氮、血肌酐、总胆红素、丙氨酸转氨酶的水平,SIRS、MODS的发生率均显著优于对照组(均P<0.05)。结论 UTI应用于早期烧伤患者,能显著降低患者体内炎症反应,减少对患者肝肾功能的损害,降低SIRS及MODS的发生率,具有重要的临床意义。
Objective To investigate the clinical value of ulinastatin (UTI) in patients with early stage burn. Methods A total of 130 hospitalized patients with burn in our hospital from November 2013 to June 2015 were selected and randomly divided into UTI group (n = 65) and control group (n = 65). The patients in the control group were given routine first-aid treatment and the experimental group was given UTI treatment on the basis of the control group. The levels of tumor necrosis factor-α (TNF-α) and interleukin-8 (IL-8), serum urea nitrogen, serum creatinine, total bilirubin and alanine aminotransferase in the serum of the two groups were compared at the same time Incidence of systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction syndrome (MODS). Results After the same treatment time, the levels of TNF-α and IL-8, the levels of urea nitrogen, serum creatinine, total bilirubin and alanine aminotransferase, SIRS and MODS in UTI group were significantly higher than those in control group All P <0.05). Conclusions UTI can be used in patients with early stage burn and can significantly reduce the inflammatory reaction, reduce the damage to liver and kidney function and reduce the incidence of SIRS and MODS in patients with early stage burn. It has important clinical significance.