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目的：为了观察康莱特与化疗联用对食管癌的治疗效果。方法：将９５例中晚期食管癌患者随机分入康莱特联用ＤＤＰ＋５－ＦＵ组和单纯ＤＤＰ＋５－ＦＵ化疗组。结果：１）两组有效率分别为７３％和５３％，差异显著（Ｐ＜０．０５），前者的完全缓解率也较高；２）联用组治疗前后ＫＰＳ评分改善及稳定者也明显高于单纯化疗组（Ｐ＜０．０１）；３）化疗结束后联用组有３／４患者能够及时放疗，而单纯化疗组只有不足１／２患者能按期放疗。结论：长期应用康莱特能使患者ＫＰＳ提高或保持稳定。有助于提高疗效，延长缓解期。
Objective: To observe the therapeutic effect of Kanglaite combined with chemotherapy on esophageal cancer. METHODS: Ninety-five patients with advanced esophageal cancer were randomly assigned to KLT plus DDP+5-FU and DDP+5-FU chemotherapy alone. Results: 1) The effective rates of the two groups were 73% and 53%, respectively. The difference was significant (P<0.05). The complete remission rate of the former was also higher; 2) The improvement of KPS scores before and after treatment in the combination group was also significant. It was higher than chemotherapy alone (P<0.01); 3) After chemotherapy, 3/4 patients in the combination group were able to receive radiotherapy in time, while less than 1/2 of patients in the chemotherapy alone group were able to receive radiotherapy on schedule. Conclusions: Long-term use of KLT can increase or maintain stable KPS in patients. Helps to improve efficacy and prolong remission.