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应用免疫组化ABC法,观察DH_7识别抗原在53例胃粘膜不典型增生和胃癌组织中的表达。结果显示胃粘膜不典型增生和高分化腺癌的阳性率分别为7/7,9/9;低分化腺癌阳性率为14/16。其中高分化腺癌与低分化腺癌的强阳性(+++)率分别为7/9和1/16,两者间具有高度显著性差异(P<0.01)。2例未分化腺癌均呈阴性。在其它胃癌组织类型中,粘液腺癌阳性率为9/9,粘液细胞癌(即印戒细胞癌)阳性率为2/10。提示DH_7识别抗原不能判定胃粘膜病变的良恶性质,而该抗原的表达可能与肿瘤的增生、分化有一定关系。
Immunohistochemical ABC method was used to observe the expression of DH_7 antigen in 53 gastric dysplasia and gastric cancer tissues. The results showed that the positive rates of gastric dysplasia and well-differentiated adenocarcinoma were 7/7 and 9/9 respectively; the positive rate of poorly differentiated adenocarcinoma was 14/16. The strong positive (+++) rates of well-differentiated adenocarcinoma and poorly-differentiated adenocarcinoma were 7/9 and 1/16, respectively. There was a highly significant difference between the two (P<0.01). Two cases of undifferentiated adenocarcinoma were negative. In other types of gastric cancer, the positive rate of mucinous adenocarcinoma was 9/9, and the positive rate of mucinous cell carcinoma (that is, signet-ring cell carcinoma) was 2/10. It is suggested that DH_7 antigen recognition can not determine the benign and malignant nature of gastric mucosal lesions, and the expression of this antigen may be related to the proliferation and differentiation of tumors.