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分别用硝酸（硝酸组）和弹力酶（蛋白酶组）滴入兔气管复制出小气道炎症-肺气肿和局限性肺气肿动物模型。观察Ⅳ型胶原酶和金属蛋白酶组织抑制因子（TIMP）在肺气肿组织中的表达。结果显示硝酸组和蛋白酶组扩张的肺泡壁Ⅳ型胶原酶和TIMP的表达均明显增强。提示Ⅳ型胶原酶与肺气肿的发病有关。
The nitric acid (nitric acid group) and elastase (protease group) were instilled into the trachea of rabbits to reproduce the model of small airway inflammation-emphysema and local emphysema respectively. To observe the expression of type Ⅳ collagenase and tissue inhibitor of metalloproteinase (TIMP) in emphysema. The results showed that the expression of type Ⅳ collagenase and TIMP in alveolar wall in nitric acid group and protease group were significantly increased. Tip type Ⅳ collagenase and the incidence of emphysema.