葡萄球菌激酶（Sak）是一种激活溶纤维蛋白的制剂，它与纤溶酶原（Plg）形成1:1的复合体，使后者转变为纤溶酶（Pli）后激活其它Plg分子变为Pli。在血浆中Sak能溶解纤维蛋白凝块而没有纤维蛋白原降解。在动物模型中，Sak在溶解血块方面似与链激酶等效，但溶解富含血小板的血栓更有效。在急性心肌梗塞病人中试用证实有强的溶血栓作用；但从第3周起所有病人均出现抗Sak中和抗体，需要更详细的研究以明确其疗效。 Staphylokinase (Sak), a fibrinolytic activator, forms a 1: 1 complex with plasminogen (Plg) and converts the latter to plasmids (Pli) to activate other Plg molecules For Pli. Sak in the plasma can dissolve fibrin clot without fibrinogen degradation. In animal models, Sak appears to be equivalent to streptokinase in resolving clots, but dissolving platelet-rich thrombi is more effective. Acute myocardial infarction in patients with trial confirmed strong thrombolytic effect; but from the 3rd week all patients appeared anti-Sak neutralizing antibodies, the need for more detailed study to clarify its efficacy.