乌头碱属双酯类生物碱,其毒性极大,有敬剂量与中毒量接近,口服3—5mg 即可造成死亡。其酯键水解后生成单酯的苯甲酰乌头碱(Picraconitine),再进一步水解生成氨基醇类的乌头原碱(aconine)。反应式如下:苯甲酰乌头碱与乌头原碱的毒性大大低于乌头碱。为保证用药安全,一般中药材炮灸和制剂生产过程均使所含乌头碱有不同程度的水解,并需控制乌头碱限量。乌头碱的限量检查常用薄层层析,其含量测定方法有用薄层扫描的报导,但该法仪器昂贵,不能普及推广。本文应用自制的涂碳 PVC 膜乌头碱电极,利用其对乌头碱 Aconitum is a di-alkaline alkaloid, which is extremely toxic, with a dose close to the amount of poisoning. Oral 3-5mg can cause death. After the ester bond is hydrolyzed, monoester picraconitine is formed and further hydrolyzed to produce aconoine of amino alcohols. The reaction formula is as follows: The toxicity of benzoylaconitine and aconitine is much lower than aconitine. In order to ensure the safety of medication, the production process of traditional Chinese herbal medicines, such as artillery moxibustion and preparations, causes the hydrolysis of aconitine contained in different degrees and requires the control of aconitine. The limited examination of aconitine is commonly used in thin-layer chromatography, and its content determination method is useful for thin-layer scans. However, this method is expensive and cannot be popularized. In this paper, self-made carbon coated PVC membrane aconitine electrode is used to utilize Aconitine