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目的研究儿童传染性单核细胞增多症肝功能损害的相关因素,探讨预防肝损害的方法。方法回顾性分析广州市妇女儿童医疗中心305例儿童传染性单核细胞增多症患儿的资料,分析不同年龄、性别、病程、发热时间、热峰及病情严重程度的肝功能损害发生率差异。结果 305例儿童传染性单核细胞增多症患儿中,共有195例(63.93%)患儿出现不同程度的肝功能损害,3~6岁组、男性的肝功能损害发生率(68.25%,77.77%)高于其他年龄组及女性的肝功能损害发生率。而发生肝功能损害患儿的病程(7.4±2.5)d、发热时间(8.2±3.6)d及热峰(38.48±1.72)℃明显高于未发生肝功能损害的患儿(4.4±1.3)d、(5.7±3.1)d、(37.49±1.92)℃。并且病情越重,其肝功能损害的发生率越高。差异有统计学意义(P<0.05)。结论儿童传染性单核细胞增多症肝功能损害与患儿年龄、性别、病程、发热时间、热峰及病情严重程度等有关,对肝功能损害高危患儿应加强其监护及早期护肝治疗。
Objective To study the related factors of liver damage in children with infectious mononucleosis and to explore ways to prevent liver damage. Methods The data of 305 children with infectious mononucleosis in Guangzhou Women and Children Medical Center were retrospectively analyzed. The incidence of liver dysfunction was analyzed according to age, gender, course of disease, fever time, heat peak and severity of illness. Results A total of 195 infants (63.93%) had liver dysfunction in 305 children with infectious mononucleosis syndrome. The incidence of hepatic dysfunction was 68.25% and 77.77 in males aged 3-6 years %) Higher than other age groups and women’s incidence of liver damage. The duration of fever (7.4 ± 2.5) d, fever duration (8.2 ± 3.6) days and heat peak (38.48 ± 1.72) ℃ in children with liver dysfunction were significantly higher than those in children without liver damage (4.4 ± 1.3 days) , (5.7 ± 3.1) d, (37.49 ± 1.92) ℃. And the more serious the disease, the higher the incidence of liver damage. The difference was statistically significant (P <0.05). Conclusions Children with infectious mononucleosis syndrome, liver dysfunction and age, gender, duration of disease, fever, heat peak and the severity of the disease and other related, high-risk children with impaired liver function should be strengthened care and early liver protection treatment.