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目的探讨抗核糖体P蛋白抗体在神经精神狼疮中的意义。方法采用酶联免疫吸附测定法,检测69份系统性红斑狼疮患者血清(包括神经精神狼疮患者35例,无神经精神症状狼疮患者34例)和12份神经精神狼疮患者脑脊液中的抗核糖体P蛋白抗体。结果血清小抗核糖体P蛋白抗体在神经精神狼疮患者中的阳性率为57%,在无神经精神症状狼疮患者中的阳性率仅为3%,二者在抗体水平和阳性率上差异有统计学意义(P<0.05)。弥漫性神经精神狼疮患者抗体阳性率为67%,显著高于局灶性神经精神狼疮患者的14%(P<0.05)。神经精神狼疮中20例抗核糖体P蛋白抗体阳性患者系统性红斑狼疮疾病活动指数显著高于15例阴性患者(P<0.05);阳性患者精神症状(类精神分裂症、抑郁症)出现率明显高于阴性患者(P<0.05)。12例神经精神狼疮患者脑脊液中抗核糖体P蛋白抗体均为阴性。结论血清中抗核糖体P蛋白抗体水平与神经精神狼疮的精神症状及病情活动度高度相关。
Objective To investigate the significance of anti-ribosomal P protein antibody in neuropsychiatric lupus. Methods Enzyme linked immunosorbent assay was used to detect the levels of anti-ribosomal P in cerebrospinal fluid of 69 patients with systemic lupus erythematosus (including 35 patients with neuroleptic lupus and 34 patients without neuroleptic lupus) and 12 patients with neuroleptic lupus Protein antibody. Results The positive rate of serum anti-ribosomal P protein antibody in patients with neuropathic lupus was 57%, while that in patients without neuropathic symptoms was only 3%. There was statistical difference between antibody level and positive rate Significance (P <0.05). The positive rate of antibodies in patients with diffuse neuropsychiatric lupus was 67%, significantly higher than that in patients with focal neuroleptic lupus (14%, P <0.05). The activity index of systemic lupus erythematosus was significantly higher in 20 patients with positive anti-ribosomal P protein than that in 15 patients with neuropathic lupus (P <0.05). The incidence of psychiatric symptoms (schizophrenia and depression) was significantly higher in positive patients Higher than negative patients (P <0.05). Anti-ribosomal P protein antibodies in cerebrospinal fluid of 12 patients with neuropathic lupus were negative. Conclusion The level of anti-ribosomal protein P in serum is closely related to the psychiatric symptoms and activity of neuropsychiatric lupus.