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目的 探讨缺血性卒中患者急性期发生的卒中后抑郁障碍(poststroke depression,PSD)与1年卒中复发风险的相关性.方法 根据《美国精神障碍诊断与统计手册(第4版)》抑郁障碍诊断标准,对1897例连续入组的急性缺血性卒中住院患者,在卒中后2周进行抑郁障碍的诊断；利用logistic回归分析计算PSD患者的1年卒中复发OR值及95％可信区间(CI).结果 共1460例患者的随访数据完整,其中390例(26.7％)患者在卒中后2周符合PSD诊断,一年累计卒中复发153例(10.5％).多变量logistic回归分析显示,与非PSD患者比较,PSD患者的1年卒中复发风险增加48％(OR=1.48；95％ CI:1.01 ～2.15；P＜0.05).结论 缺血性卒中患者急性期发生的PSD可能增加1年卒中复发风险.“,”Objective To investigate whether depression in acute phase of ischemic stroke could increase risk of recurrent stroke at 1 year.Methods This was a multi-centered prospective cohort study.1897 patients with acute ischemic stroke were enrolled consecutively.The Diagnostic and Statistical Manual of Mental Disorders,fourth edition (DSM-Ⅳ) was used as criteria for diagnosis of depression.Results In 1460 patients who complete follow-up data,967 (66.2％) were male with a mean of 61.1 years of age,and 493 (33.8％) were female with mean of 64.5 years of age.There were 390 (26.7％) cases of depression at 2 weeks,and 153 (10.5％) cases of cumulative recurrent stroke at 1 year.Multivariate logistic regression analysis showed a 48％ increase of risk of recurrent stroke at 1 year in patients with depression compared to patients without depression (OR =1.48,95％ CI:1.01-2.15,P ＜ 0.05).Conclusions Depression in acute phase of ischemic stroke is possibly related with a higher risk of recurrent stroke at 1 year.