自1960年Cooke报告了一种伴有口腔及口咽部粘膜角化或非角化状态的,复发性的,大量散在的,浅表的口腔溃疡病,他认为在临床上类似于单纯疱疹,但无相应的组织改变;它的早期病变的组织学特征与阿弗他溃疡相似;可以由2%四环素含漱而得到很快短期疗效。Cooke对这种病变称之谓“疱疹样溃疡”。虽然这一临床病变的本质很多尚 Since 1960, Cooke reported a recurrent, massive, superficial oral ulcer disease with oral and oropharyngeal mucosal keratosis or nonkeratinization that he considered clinically similar to herpes simplex, But no corresponding changes in the organization; its histological features of early lesions and aphthous ulcer similar to; 2% tetracycline can be rinsed quickly and short-term effect. Cooke called the disease “herpes-like ulcers.” Although the nature of this clinical disease is still numerous