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布鲁氏菌病是威胁人类健康和畜牧业发展的重要的传染病,同时也是一种生物武器,是世界性的公共卫生问题。以双向凝胶电泳、生物质谱及生物信息学为主要技术支撑的蛋白质组学研究技术的完善进步,蛋白质组学研究将不断深入发展。近年来,蛋白质组学研究技术已应用到布鲁氏菌病研究领域中,在医学研究领域中不仅能为阐明布鲁氏菌活动规律提供理论基础,也能为探讨布鲁氏菌病的致病机理、疾病诊断、疾病防治和新型疫苗的研制等提供重要的理论依据和实际解决途径,从而为布鲁氏菌病的研究做出重大贡献。
Brucellosis is an important infectious disease that threatens the development of human health and livestock husbandry. It is also a biological weapon and a worldwide public health issue. Two-dimensional gel electrophoresis, bio-mass spectrometry and bioinformatics as the main technical support for the improvement of proteomics research progress, proteomics research will continue to deepen. In recent years, proteomics research has been applied to the field of brucellosis in the field of medical research, not only to elucidate the law of activity of brucellosis provide a theoretical basis, but also for the study of brucellosis Pathogenesis, disease diagnosis, disease prevention and development of new vaccines provide an important theoretical basis and practical solutions to make a significant contribution to the study of brucellosis.