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目的探讨细胞毒性T淋巴细胞相关抗原(CTLA)-4基因启动子区-1722位点(T/ C)多态性和-1661位点(A/G)多态性与中国汉族人群中胃癌的相关性。方法采用聚合酶链反应(PCR)-限制性片段长度多态性(RFLP)方法,对183例胃癌患者和116例中国汉族正常对照者进行CTLA-4基因-1722位点和-1661位点多态性检测。结果与正常对照组比较,胃癌患者CTLA- 4基因-1661位点AA基因型频率,-1661位点A等位基因频率显著降低(65．6% vs 84．5%；P＜0．01；odds ratio=0．349 9；95%CI=0．194 3-0．629 9；81．1% vs 91．8%；P＜0．01；odds ratio= 2．604 0；95%CI=1．521-4．458)。结论CTLA-4基因启动子区-1661位点A等位基因与中国汉族胃癌显著相关。
Objective To investigate the polymorphisms of -1722 (T / C) and -1661 (A / G) polymorphisms in CTLA-4 gene promoter region and gastric cancer in Chinese Han population Correlation. Methods The genotypes of CTLA-4 gene -1722 locus and -1661 locus in 183 gastric cancer patients and 116 Chinese Han normal controls were analyzed by polymerase chain reaction-restriction fragment length polymorphism (RFLP) State detection. Results Compared with the normal control group, the frequency of AA genotype at -1661 and the allele A at -1661 were significantly lower in patients with gastric cancer (65.6% vs 84.5%, P <0.01; odds ratio = 0.349 9; 95% CI = 0.194 3-0.629 9; 81.1% vs 91.8%; P <0.01; odds ratio = 2.604 0; 95% CI = 1.521-4.458). Conclusions A allele at -1661 in CTLA-4 gene promoter region is significantly associated with gastric cancer in Chinese Han population.