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目的 探讨血管内皮生长因子 (vascularendothelialgrowthfactor,VEGF)和转化生长因子 β1(transforminggrowthfactor β1,TGF β1)的表达与鼻息肉复发关系。方法 6 0例内窥镜鼻窦术后鼻息肉复发病人 ,用SP免疫组化染色法比较VEGF和TGF β1的表达。结果 VEGF和TGF β1在鼻息肉组织的血管内皮细胞和腺体细胞的表达明显高于中鼻甲组织 (P <0 0 1) ;鼻息肉临床分型与VEGF和TGF β1的表达无关。结论 VEGF和TGF β1的表达可能与鼻息肉复发有关 ,术后定期合理的鼻窦内窥镜随访是预防和减少复发的重要手段。
Objective To investigate the relationship between the expression of vascular endothelial growth factor (VEGF) and transforming growth factor β1 (TGF β1) and the recurrence of nasal polyps. Methods Sixty patients with recurrent nasal polyps after endoscopic sinus surgery were enrolled in this study. The expressions of VEGF and TGFβ1 were compared by SP immunohistochemical staining. Results The expression of VEGF and TGFβ1 in the vascular endothelial cells and glandular cells of nasal polyps was significantly higher than that in middle turbinate tissues (P <0.01). The clinical classification of nasal polyps was not related to the expression of VEGF and TGFβ1. Conclusion The expression of VEGF and TGF-β1 may be related to the recurrence of nasal polyps. The regular and reasonable follow-up of endoscopic sinus surgery is an important means to prevent and reduce recurrence.