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医院药剂科开展自制抗生素制剂的效价检定工作是保证药品质量、保障人民用药安全有效的重要措施之一。目前一般医院的抗生素制剂均不测定其微生物效价,如链霉素眼药水即为非“三级标准”所收载的医院制剂,笔者根据中国药典“抗生素微生物检定法”,设计了本测定方法,供基层医疗单位开展抗生素效价检定和生物统计方法的参考。一、测定原理系根据在一定剂量范围内,抗生素的对数剂量与其所产生的抑菌圈的直径成线性关系,利用量反应平行线的原理而设计。二、设备仪器、用具及材料
It is one of the important measures to ensure the quality of medicines and ensure the safety and effectiveness of medicines for people to carry out the titer test of homemade antibiotics preparations in the hospital pharmacy department. At present, the general hospital antibiotic agents are not measured its microbial titer, such as streptomycin eye drops that non-“third-class standards” contained in the hospital preparations, the author according to the Chinese Pharmacopoeia “antibiotics microbial test method” designed this test Method for the primary medical units to carry out antibiotic potency test and biostatistical reference. First, the determination of the Department is based on a certain dose range, the logarithmic dose of antibiotics and antibacterial ring diameter generated by its linear relationship between the use of quantitative response to the principle of parallel lines designed. Second, equipment, apparatus and materials