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目的探讨强力霉素两种不同剂量药物浓度治疗地方性斑疹伤寒的临床疗效,以及不同药物浓度与出现不良反应的关系。方法观察我院5年来收治的地方性斑疹伤寒80例,进行前瞻性研究,并进行统计学分析。结果两种不同药物浓度的强力霉素治疗地方性斑疹伤寒患者,临床症状及体征的改善恢复时间上差异无统计学意义,但不同药物浓度出现的不良反应有较大的差异,表现为强力霉素一日用量为0.05g与用量为0.1g的患者对比出现消化道反应较轻、较缓慢,重度反应较少。结论强力霉素用量减少一半,不影响临床疗效,并且显著降低患者可能出现的不良反应,故建议如用强力霉素治疗地方性斑疹伤寒可以减量到正常用量的一半剂量。
Objective To investigate the clinical efficacy of two different doses of doxycycline in the treatment of endemic typhus as well as the relationship between different drug concentrations and adverse reactions. Methods 80 cases of endemic typhus admitted in our hospital over the past five years were studied prospectively and statistically analyzed. Results There was no significant difference in the recovery time of clinical symptoms and signs between the two different drug concentrations of doxycycline in the treatment of endemic typhus, but there were significant differences in the adverse reactions of different drug concentrations, showing strong In comparison with patients taking 0.05g daily doses and 0.1g daily doses, the gastrointestinal reaction was milder and slower with less severe reactions. Conclusions The dosage of doxycycline is reduced by half without affecting the clinical curative effect and significantly reducing the possible adverse reactions of the patients. Therefore, it is suggested that the treatment of endemic typhus with doxycycline can be reduced to half of the normal dosage.