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目的探讨抗幽门螺杆菌(Hp)序贯疗法对消化性溃疡并出血的效果。方法 50例消化性溃疡并出血患者,随机分为对照组与观察组,各25例。对照组采用常规疗法进行治疗,观察组采用抗Hp序贯疗法进行治疗。经过1个月的治疗后,观察和对比两组患者的治疗效果、胃溃疡的愈合情况、止血时间和止血率。结果观察组Hp转阴总有效率为92%,明显高于对照组的60%,差异具有统计学意义(P<0.05)。观察组胃溃疡愈合总有效率为96%,明显高于对照组的76%,差异具有统计学意义(P<0.05)。观察组患者止血率为100%,止血时间为(28.95±16.00)h,均优于对照组的60%、(38.69±16.20)h,差异均具有统计学意义(P<0.05)。结论抗Hp序贯疗法治疗消化性溃疡并出血效果显著,能够有效地抑制Hp繁殖,促使溃疡面获得改善,值得临床广泛应用。
Objective To investigate the effect of anti-Helicobacter pylori (Hp) sequential therapy on peptic ulcer bleeding. Methods Fifty patients with peptic ulcer and hemorrhage were randomly divided into control group and observation group, with 25 cases in each group. The control group received conventional therapy, and the observation group received anti-Hp sequential therapy. After one month’s treatment, the therapeutic effect, the healing of gastric ulcer, the time to stop bleeding and the rate of bleeding were observed and compared between the two groups. Results The total effective rate of negative Hp in the observation group was 92%, which was significantly higher than that in the control group (60%), the difference was statistically significant (P <0.05). The total effective rate of gastric ulcer healing in observation group was 96%, which was significantly higher than 76% in control group, the difference was statistically significant (P <0.05). The bleeding rate in the observation group was 100% and the bleeding time was (28.95 ± 16.00) h, both of which were better than 60% and 38.69 ± 16.20 h in the control group, respectively. The difference was statistically significant (P <0.05). Conclusion Anti-Hp sequential therapy for peptic ulcer bleeding and significant effect, can effectively inhibit the reproduction of Hp, prompting the improvement of ulcers, it is widely used in clinical.