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低剂量静脉输入全麻药氯胺酮可治愈严重的支气管哮喘。文献报道:一位顽固性呼吸困难和喘息的女性患者(检查发现中枢性紫绀和满肺哮鸣音),在其它方法无效时,开始低剂量静脉滴入氯胺酮,平均剂量为15μg/kg/分,另外约每3小时静注安定5mg,两天后患者自动呼吸接近正常,仅留有最小的呼气性哮鸣音。氯胺酮的作用机制是由于其可阻滞迷定神经并可直接松驰平滑肌,但更重要是由于它的拟交感性能而使内源性儿茶酚胺血浆浓度增加所致。酚妥拉明、酚苄胺等α受体阻断剂临床上已对一些β受体激动剂产生耐药性的顽固
Low-dose intravenous anesthetic ketamine can cure severe bronchial asthma. Reported in the literature: a refractory dyspnea and wheezing female patients (examination revealed central cyanosis and lung full wheeze), in the other methods ineffective, began low-dose intravenous ketamine, the average dose of 15μg / kg / min In addition, about every 3 hours intravenous stability 5mg, two days after the patient automatically breathe close to normal, leaving only the smallest expiratory wheeze. The mechanism of action of ketamine is due to its ability to block the fastigial nerve and to relax the smooth muscle directly, but more importantly due to the increased sympathetic properties of endogenous catecholamines. Phentolamine, phenylethylamine and other alpha-blockers have clinically resistant to some beta-agonists