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目的观察胃痞颗粒对胃癌癌前病变患者黏膜上皮细胞凋亡及调控蛋白表达的影响。探讨胃痞颗粒治疗胃癌癌前病变的作用机制。方法46例患者随机分为治疗组30例,对照组16例,治疗组用胃痞颗粒一号与胃复春片一号,对照组用胃痞颗粒二号与胃复春片二号,连续应用6个月,进行相关检测。结果治疗组患者细胞凋亡指数治疗后比治疗前明显提高,也比对照组治疗后升高显著;Bcl-2、P53、Fas蛋白表达结果治疗组与对照组相比差异均有统计学意义。结论胃痞颗粒对胃黏膜癌前病变有逆转治疗作用。胃痞颗粒通过抑制Bcl-2、P53(突变型)蛋白表达,促进Fas蛋白表达和细胞凋亡指数增加,从而有利于胃黏膜异型增生的上皮细胞发生凋亡,这可能是胃痞颗粒治疗癌前病变获效的机制之一。
Objective To observe the effect of Weiqi granules on the apoptosis of gastric epithelial cells and the expression of regulatory proteins in gastric precancerous lesions. To explore the mechanism of Weiqi granules in the treatment of gastric precancerous lesions. Methods Forty-six patients were randomly divided into treatment group (n = 30) and control group (n = 16). The treatment group was treated with Weiqi granule No.1 and Weifuchun tablets No.1, while the control group was treated with Weifu granule No.2 and Weifuchun Tablet No.2. Application for 6 months, relevant testing. Results The apoptotic index of the patients in the treatment group was significantly higher than that before the treatment, and was also significantly higher than that of the control group after treatment. The expression of Bcl-2, P53, and Fas protein was significantly different between the treatment group and the control group. Conclusion Weiqi granules have a reversal effect on gastric precancerous lesions. Stomach granules promote apoptosis of epithelial cells of gastric dysplasia by inhibiting the expression of Bcl-2 and P53 (mutant) proteins, promoting Fas protein expression and increasing apoptosis index. One of the mechanisms for the effectiveness of pre-lesions.