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目的了解实施乙型肝炎(乙肝)疫苗干预措施后人群乙肝病毒(HBV)感染状况和抗体水平。方法2005年在河北省正定县试点乡8个自然村,采集人群血清标本10010份,用固相放射免疫(SPRIA)法检测血清标本的乙肝病毒表面抗原(HBsAg)和乙肝病毒表面抗体(抗-HBs),使用EPI info和SAS软件进行统计处理。结果免疫后人群中HBsAg平均阳性率为5.32%(标化率为4.82%),与免疫前1983年的8.57%(标化率为8.16%)相比降低了37.92%(标化率为40.93%),其中1~19岁人群HBsAg平均阳性率为1.46%,<15岁儿童HBsAg阳性率为0.49%,明显低于免疫前同年龄组人群。免疫后整体人群保护性抗-HBs(S/N≥10.0)平均阳性率为46.86%,其中1~19岁为53.77%,明显高于免疫前1983年对应年龄组人群的38.32%。结论实施乙肝疫苗干预措施后1~19岁人群HBsAg阳性率达到低流行国家水平,≥20岁人群HBV感染情况无明显变化。
Objective To understand the status of hepatitis B virus (HBV) infection and antibody levels after the implementation of Hepatitis B (HBV) vaccine interventions. Methods In 2005, a total of 10 100 serum samples were collected from 8 villages in Pilot Township, Zhengding County, Hebei Province. Serum HBsAg and HBsAg were detected by solid phase radioimmunoassay (SPRIA) ), Using EPI info and SAS software for statistical processing. Results The average positive rate of HBsAg in the population after immunization was 5.32% (standardization rate was 4.82%), which was 37.92% lower than that of 8.57% before 1983 (standardization rate was 8.16%) (standardization rate was 40.93% ), Of which the average positive rate of HBsAg was 1.46% in 1- 19-year-olds and 0.49% in <15-year-old children, which was significantly lower than that in the same age group. The average positive rate of protective anti-HBs (S / N≥10.0) in the population after immunization was 46.86%, of which 53.77% were between 19 and 19 years old, which was significantly higher than 38.32% of the corresponding age group before immunization. Conclusions The HBsAg positive rate of 1- 19-year-old population reaches the national level of low-prevalence after the hepatitis B vaccine intervention. There is no significant change of HBV infection in ≥20-year-old population.