论文部分内容阅读
自人类有历史记载以来，铜及其配合物即用作药物。铜是人体必需的金属元素。人体的正常代谢过程需要它们，但无法体内合成，因此，需要每天从饮食摄取和吸收。生物药学家和研究者以极大的努力彻底地了解铜及其配合物在生物体系中的作用，希望获得更多地信息以利于人类疾病的预防和治疗。本综述评述了铜在组织中的分配和代谢、铜依赖酶、在病态时铜的非正常代谢、铜配合物的药疗活性和抑制氧自由基的产生。
Since humans have historical records, copper and its complexes are used as drugs. Copper is a necessary metal element of the body. The body’s normal metabolic processes require them, but they can not be synthesized in vivo and, therefore, require daily intake and absorption from the diet. Biopharmacologists and researchers have made a great deal of effort to thoroughly understand the role of copper and its complexes in biological systems in the hope of gaining more information for the prevention and treatment of human diseases. This review reviews the copper distribution and metabolism in tissues, copper-dependent enzymes, abnormal copper metabolism in pathological conditions, the pharmacological activity of copper complexes and the inhibition of oxygen free radical production.