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目的:探讨Ecadherin、αcatenin、βcatenin和γcatenin与胃癌发生及胃癌生物学行为的关系。方法:用免疫组织化学方法检测Ecadherin及αcatenin、βcatenin、γcatenin在43例胃癌,22例胃癌前病变及10例正常胃粘膜中的表达。结果:在胃癌前病变中Ecadherin,αcatenin、βcatenin、γcatenin的异常表达率分别为22.7%、22.7%、18.2%、27.3%,分别与胃癌Ecadherin(53.5%),αcatenin(55.8%)、βcatenin(51.2%)的异常表达率相比差异有显著性(P<0.05)。进展期胃癌异常表达率较早期胃癌高,除γcatenin外差异均有显著意义(P<0.05或P<0.01)。低分化胃癌Ecadherin的异常表达率较高,胃癌浸润到浆膜外及伴随淋巴结转移时Ecadherin、βcatenin的异常表达率升高(P<0.05或P<0.01)。76.7%的胃癌及50.0%的胃癌前病变Ecadherin系统中至少有一项表达异常,二者差异有显著性(P<0.05),且至少有一项为表达异常病人的淋巴结转移率明显高于无蛋白异常表达者(P<0.01)。结论:Ecadherin及部分相关蛋白的表达异常与胃癌的分化程度、临床分期、浸润深度及淋巴结转移密切相关,Ecadherin系统在由胃不典型增生转化为胃癌的过程中起作用,联合检测Ecadherin及αcatenin、βcatenin、γcatenin可提高检测结果的参考价值。
Objective: To investigate the relationship between Ecadherin, αcatenin, β-catenin and γ-catenin and the biological behavior of gastric cancer and gastric cancer. Methods: Immunohistochemistry was used to detect the expression of Ecadherin and αcatenin, β-catenin, and γcatenin in 43 cases of gastric cancer, 22 cases of gastric precancerous lesions and 10 cases of normal gastric mucosa. RESULTS: The abnormal expression rates of Ecadherin, αcatenin, β-catenin, and γcatenin in precancerous lesions were 22.7%, 22.7%, 18.2%, and 27.3%, respectively, and Ecadherin (53.5%), αcatenin (55.8%), and βcatenin (51.2). The abnormal expression rate of %) was significantly different from the difference (P<0.05). The abnormal expression rate of advanced gastric cancer was higher than that of early gastric cancer, with significant differences except γcatenin (P<0.05 or P<0.01). The abnormal expression rate of Ecadherin in poorly differentiated gastric cancer was higher, and the abnormal expression rate of Ecadherin and β-catenin increased when gastric cancer infiltrated into the extrascleral and lymph node metastasis (P<0.05 or P<0.01). 76.7% of gastric cancer and 50.0% of gastric precancerous lesions had at least one abnormal expression in the Ecadherin system. There was a significant difference between the two (P<0.05), and at least one of the patients with abnormal expression had significantly higher lymph node metastasis rate than protein-free abnormalities. Expressors (P<0.01). Conclusion: The abnormal expression of Ecadherin and some related proteins is closely related to the degree of differentiation of gastric cancer, clinical stage, depth of invasion, and lymph node metastasis. The Ecadherin system plays a role in the transition from gastric dysplasia to gastric cancer. Combined detection of Ecadherin and αcatenin, Βcatenin and γcatenin can increase the reference value of the test results.