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作者利用FMR1的cDNA筛选了非洲蟾蜍laevis卵巢cDNA文库,所得到的两个克隆中,1个与人类的FMR1氨基酸有86％的同源,在其5′非转译区没有发现cGG重复,这提示cGG重复可能只在哺乳动物中出现。另1个克隆被称之为FXR1。非洲蟾蜍laevis FXR1 cDNA又被用来筛选人类Hela细胞文库得到了人类的FXR1 cDNA。顺序分析结果显示,FxR1与FMR1在KH区有86％的氨基酸顺序同源,在氨基末端区域有70％的同源,并都含有精氨酸富集区,但在羧基区域存在较大的差异,只有6％的
Using the cDNA of FMR1, the authors screened the larvis ovary cDNA library of Xenopus laevis. Of the two clones obtained, one was 86% homologous to human FMR1 amino acids and no cGG repeats were found in the 5 ’untranslated region, suggesting that cGG repeats may only occur in mammals. The other clone is called FXR1. The African toad laevis FXR1 cDNA was used to screen the human Hela cell library for human FXR1 cDNA. Sequence analysis showed that FxR1 and FMR1 have 86% amino acid sequence homology in KH region, 70% homology in the amino terminal region and all contain arginine-rich region, but there is a big difference in carboxyl region , Only 6%