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目的 对比观察诱导化疗联合后程加速超分割放疗 (诱导组 )和同时期化疗联合后程加速超分割放疗 (同期组 )治疗中晚期鼻咽癌的毒副反应、有效率及生存率。方法 3 2例中晚期鼻咽癌应用羟基喜树碱 (HCTP)诱导化疗联合后程加速超分割放射治疗 ,48例类似病人应用DDP加 5 Fu化疗同期联合后程加速超分割放射治疗。结果 诱导组总有效率 10 0 % ,其中CR87.5 % (2 8/3 2 ) ,同期组总有效率 10 0 % ,其中CR85 .42 % (4 1/4 8) ,两组之间无显著性差别 (P =0 .79) ;但经CT检查证实鼻咽肿瘤完全消退率同期组达 75 .76% ,而诱导组仅 42 .1% ,同期组比诱导组高 (P =0 .0 3 ) ;1年生存率 :诱导组为 93 .8% (3 0 /3 2 ) ,同期组为 91.7% (4 4 /4 8) ,两组之间差别无显著性意义 (P =0 .93 )。但诱导组的毒副反应比同期组轻 (P <0 .0 5 )。结论 HCTP诱导化疗联合后程加速超分割放疗与DDP加 5 Fu化疗同期联合后程加速超分割放射治疗对中晚期鼻咽癌的疗效无差异 ,但前者毒副反应较轻。
Objective To compare and observe the side effects, efficiency and survival rate of induction chemotherapy combined with late-course hyperfractionated radiotherapy (induction group) and concurrent chemotherapy plus late-course hyperfractionated radiotherapy (concurrent group) in the treatment of advanced and advanced nasopharyngeal carcinoma. Methods 32 cases of advanced nasopharyngeal carcinoma with hydroxycamptothecin (HCTP) induction chemotherapy combined with late course accelerated hyperfractionation radiotherapy, 48 cases of similar patients with DDP plus 5 Fu chemotherapy combined with late-course accelerated hyperfractionation radiotherapy. Results The total effective rate of the induction group was 100%, of which CR 87.5% (28/3 2), the same period the total effective rate 100%, of which CR 85.42% (4 1/4 8), between the two groups no (P = 0.79). However, CT examination confirmed that the complete regression rate of nasopharyngeal tumors was 75.76% in the same period, compared with 42.1% in the induction group and higher in the concurrent group than in the induction group (P = 0.79). The 1-year survival rate was 93.8% (3 0/3) in the induction group and 91.7% (4 4/48) in the same period. There was no significant difference between the two groups (P = 0 .93). However, the toxic side effects in the induction group were lighter than those in the same period (P <0.05). Conclusions There is no difference in the curative effect between HCTP induction chemotherapy combined with late-course accelerated hyperfractionation and DDP plus 5 Fu chemotherapy plus late-course accelerated hyperfractionation radiation therapy for advanced or intermediate stage nasopharyngeal carcinoma. However, the former has mild toxicity.