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作者自1944年以来一直从事于抗生素的研究工作。到1951年青霉素、链霉素、氯霉素等被应用于临床上,建立了由细菌、立克次氏体引起疾病的化疗方法。1953年,抗生素的研究扩展到抗肿瘤抗生素的研究。在1957年抗性菌株在病人身上出现,使得抗细菌抗生素的研究得以发展。通过对β-内酰胺抗生素、氨基糖苷抗生素类的研究,从而对用于抗感染治疗的β-内酰胺、氨基糖苷类衍生物及其类似物的研究得到了发展。
The author has been engaged in the research of antibiotics since 1944. By 1951, penicillin, streptomycin and chloramphenicol were applied clinically to establish a chemotherapy method for diseases caused by bacteria and rickettsia. In 1953, the study of antibiotics extended to the study of antitumor antibiotics. The emergence of resistant strains in patients in 1957 led to the development of antibiotic-resistant research. Studies of β-lactam antibiotics and aminoglycoside antibiotics have led to the development of studies on β-lactams, aminoglycoside derivatives and their analogs for anti-infective therapy.