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本文对１２例小儿感染致多系统器官功能衰竭死亡病例进行临床及病理分析。临床表现有发热、外周血白细胞总数增高、心率增快、呼吸困难、呕吐、意识障碍、无尿等。其中发生二器官功能衰竭３例．三器官功能衰竭３例，四器官功能衰竭６例。病理学检查见多器官组织内炎细胞浸润；脏器充血、水肿、出血、ＤＩＣ形成；肠粘膜变性、坏死：淋巴免疫器官病变等。本文在形态学上进一步证实了多系统器官功能衰竭发生的炎症介质学说、微循环障碍、肠源性感染和免疫机能下降的综合作用机理。
In this paper, 12 cases of pediatric infection caused by multiple system organ failure death cases for clinical and pathological analysis. Clinical manifestations of fever, increased total number of peripheral white blood cells, heart rate, dyspnea, vomiting, disturbance of consciousness, anuria and so on. Two cases of organ failure occurred in 3 cases. Three organ failure in 3 cases, four organ failure in 6 cases. Pathological examination of inflammatory cells found in multiple organ tissue infiltration; organ congestion, edema, bleeding, DIC formation; intestinal mucosal degeneration and necrosis: lymphoid immune organ lesions. This article further confirms in morphological multi-system organ failure of the inflammatory mediator theory, microcirculation, intestinal infection and immune function decline in a comprehensive mechanism of action.