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目的观察喉鳞癌组织中蛋白激酶C(protein kinase C,PKC)-δ的表达水平,探讨其可能的临床意义。方法采用免疫组织化学法对60例喉鳞癌组织和20例正常喉黏膜PKC-δ蛋白表达情况进行检测。结果喉鳞癌组织中PKC-δ表达显著高于正常对照组织(P<0.01)。Ⅲ～Ⅳ期喉鳞癌组织PKC-δ表达明显高于Ⅰ～Ⅱ期(P<0.05);伴有颈淋巴结转移的喉鳞癌组织PKC-δ表达明显高于无淋巴结转移组织(P<0.05);PKC-δ表达阳性组与阴性组患者间生存率差异有统计学意义(P<0.05)。结论 PKC-δ在喉鳞癌组织中高表达,并且其表达程度与喉鳞癌的分期及是否存在淋巴结转移有关,提示PKC-δ过表达可能与喉鳞癌的发生、发展相关。
Objective To observe the expression of protein kinase C (PKC) -δ in laryngeal squamous cell carcinoma and to explore its possible clinical significance. Methods Immunohistochemistry was used to detect the protein expression of PKC-6 in 60 cases of laryngeal squamous cell carcinoma and 20 cases of normal laryngeal mucosa. Results The expression of PKC-δ in laryngeal squamous cell carcinoma was significantly higher than that in normal control (P <0.01). The expression of PKC-δ in stage Ⅲ ~ Ⅳ laryngeal squamous cell carcinoma was significantly higher than that in stage Ⅰ ~ Ⅱ (P <0.05). The expression of PKC-δ in laryngeal squamous cell carcinoma with cervical lymph node metastasis was significantly higher than that in non-lymph node metastasis ). There was significant difference in the survival rate between PKC-δ positive group and negative group (P <0.05). Conclusions PKC-δ is highly expressed in laryngeal squamous cell carcinoma and its expression is correlated with the stage of laryngeal squamous cell carcinoma and the existence of lymph node metastasis, suggesting that PKC-δ overexpression may be related to the occurrence and development of laryngeal squamous cell carcinoma.